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ea0021oc3.6 | Young Endocrinologists prize session | SFEBES2009

Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a multiple endocrine neoplasia type 1 allelle

Javid Mahsa , Walls Gerard , Lemos Manuel , Jeyabalan Jeshmi , Bazan-Peregrino Miriam , Tyler Damian , Stuckey Daniel , Seymour Len , Thakker Rajesh

Multiple endocrine neoplasia type 1 (MEN1) is characterised by the combined occurrence of pituitary, pancreatic and parathyroid tumours. The MEN1 gene encodes a 610-amino acid tumour suppressor, menin, and MEN1-associated tumours show loss of heterozygosity. This indicates that replacement of the wild-type MEN1 gene may inhibit tumourigenesis. We have previously demonstrated that a recombinant adenoviral vector could be safely injected directly into pituit...

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ea0015p191 | Endocrine tumours and neoplasia | SFEBES2008

In vivo delivery of an adenoviral gene therapy vector to pituitary tumours in Men1 deficient mice

Lemos Manuel , Harding Brian , Reed Anita , Walls Gerard , Tyler Damian , Bazan-Peregrino Miriam , Ansorge Olaf , Clarke Kieran , Seymour Len , Thakker Rajesh

The mouse knockout model for multiple endocrine neoplasia type 1 (MEN1) closely resembles the phenotype of the human disorder, with frequent development of tumours of the parathyroids, pancreas and pituitary. These tumours have loss of heterozygosity (LOH) of the Men1 locus and lack expression of the encoded protein (menin).The aim of this study was to investigate the feasibility of detecting pituitary tumours in heterozygous (Men1+/−...

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Endocrine Abstracts

Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a multiple endocrine neoplasia type 1 allelle

In vivo delivery of an adenoviral gene therapy vector to pituitary tumours in Men1 deficient mice

BiosciAbstracts